Alfred Health is a leader in health care delivery, improvement, research and education. We are the main provider of health services to people living in the inner southeast suburbs of Melbourne, from ambulatory, to inpatient and home and community based services.
ASPREE Genomics Research Assistant
- Fixed Term [12 months]
- Full Time [76 hours per fortnight]
- Alfred Hospital
The ASPREE (ASPirin in Reducing Events in the Elderly) trial randomised 19,114 healthy participants aged 70 years or older (or ≥65 among blacks and Hispanics in the United States) to low dose aspirin or placebo, with the primary endpoint a composite of death, dementia or persistent physical disability. Comprehensive clinical and phenotypic measures were collected throughout the trial, as well as peripheral blood samples from 12,223 participants at study entry and ~10,600 at 3 years. Participant follow- up is ongoing for endpoints, including incident cancer.
Clonal Haematopoiesis of Indeterminate Potential (CHIP) is development of detectable clones with somatic mutations associated with leukaemogenesis in otherwise normal, healthy people, and has been associated with increased risk of cardiovascular disease as well as blood cancers.
The project aims to investigate the extent of CHIP in the ASPREE cohort using a customized targeted next generation sequencing (NGS) amplicon assay on baseline samples and matching samples taken three years later.
The candidate will be part of an interdisciplinary team consisting of haematologists, epideminologists, genomicists, bioinformaticians and robotic liquid handling experts and will be working closely with project stakeholders to achieve the primary objectives.
The project is primarily based at the Central Clinical School, The Alfred Hosptial, Prahan Campus.
The candidate is expected to oversee and perform the custom NGS assay designed for this project and generate data from the samples of the ASPREE cohort in a timely manner.
The primary purpose of this role is to drive the genomic analysis of ASPREE biospecimens in the CHIP Sub-study through logisitical coordination of sample processing and NGS data generation. This role will play an intergral role within the ASPREE-CHIP Sub-study project and will be working with the lead investigator team, the robotic liquid handling team, the high throughput sequencing team and the bioinformatics team who are all stakeholders in this project.
- The candidate would ideally have a research degree in molecular biology or
- biochemistry or genetics (BSc(Hons), MSc or PhD). Skill 2
- Demonstrated skills in fundamental molecular biology and genomic assays in DNA or RNA next generation sequencing (NGS).
- Demonstrable experience in projects with large sample numbers.
- Demonstrable experience in high throughput molecular biology or genomics applications.
- A demonstrable appetite for learning and acquiring new skills.
- Mastery of troubleshooting in a laboratory setting. Agile ability to solve complex problems with discretion and innovation.
- Demonstrable logistics, time management and project management skills with ability to interact with multiple stakeholders.
- A demonstrable awareness of the principles of confidentiality, privacy and information handling.
- Demonstrable ability to work within a multidisciplinary team in a collegiate manner, set achievable expectations and where necessary, work independently.
- Demonstrable skills in communication, with proven ability to produce reports written and spoken to the team.
- Experience in genomics and bioinformatics analysis would be strongly desirable.
- Salary Packaging
- Discount Health Insurance
- Onsite Gym
- Child care services
Applications close (11pm 12th December 2019)
Please ensure that a CV and cover letter are submitted as part of your application.
All enquiries to Assoc. Professor Zoe McQuilten on Zoe.McQuilten@monash.edu
Alfred Health is an equal opportunity employer and is committed to attracting and retaining a diverse workforce that reflects the community we serve. Applications from Aboriginal and Torres Strait Islanders are encouraged.